What is a correct way to estimate s0 parameter for Volcano plot visualization in Perseus?

The documentation says: "Artificial within groups variance (default: 0). It controls the relative importance of t-test p-value and difference between means. At s0=0 only the p-value matters, while at nonzero s0 also the difference of means plays a role. See (Tusher, Tibshirani, and Chu 2001) for details." Now the article states: "To ensure that the variance of d(i) is independent of gene expression, we added a small positive constant s0 to the denominator of Eq. 1 (i. e. d(i) = (avg-state1(i)- avg-state2(i))/(gene_specific_scatter(i) + s0)). The coefficient of variation of d(i) was computed as a function of s(i) in moving windows across the data. The value for s0 was chosen to minimize the coefficient of variation. For the data in this paper, this computation yielded s0 = 3.3."

Now should I calculate the CV for my data and then estimate the s0 or am I missing something?