Your work is really very interesting and useful .

my sincere congratulations!!

Dear Hisham Shakhatreh , Which work is really interesting? Your answer seems to be very informative, since it received 3 recommendation. Could the persons, who gave these recommendation explain me the reasons for their recommendations.

Dear Andrzej Pelczar , as a rule scientists consider the use of a single techniques in their research as a weakness. Therefore, sooner or later additional techniques will be applied and niche, you are asking about, will disappear.

Dear Prof Geletii,

I am part of a team that has developed a new type of NQR detector, and I am looking for a practical application for it.

"Integrating Superregenerative Principles in a Compact, Power-Efficient NMR/NQR Spectrometer: A Novel Approach with Pulsed Excitation" https://arxiv.org/abs/2312.08491

Regards,

Andrzej

After an intensive search, I was able to find a precursory but forgotten publication by Prof Latosinska from 1994.

This paper showed a direct correlation between NQR signal parameters and Hammet's and Taft's constant, anti-tumour activity and maximum drug dose for a number of substances (copy of publication attached, unfortunately I was unable to find the version in English).

https://inis.iaea.org/collection/NCLCollectionStore/_Public/29/024/29024496.pdf

Drogi Andrzej,

I have sent you a private message.

Yurii

Dear Andrzej,

I think that your small and potentially cheap device may have a niche application for in-line detection of certain impurities in drugs. Or the continous monitoring of certain levels of active compounds. If it is sensitive and cheap enough it may be substitute for modern optical detection not only in pharmacy, but in food industry, environment control, chemical manufacturing, oil and gas, drilling. The idea is to put the product through it to check the certain chemical (say it will be tuned to exact frequency and only see one line but continously). Sometimes the special agent may be added in (harmless but easy to see by NQR/NMR) to check the homogeneity of mixing for example. The niche application would be not in research (where usually many devices are used to ensure the completeness) but in manufacturing, where the overall process are well known but should be monitored.

Dear Andrzej,

the gap I see in Pharmaresearch is determination of protonation of 14N (for discrim in drug-like molecules. I think to have understood that this is possible by measuring the quadrupole moment of 14N in a powder of a sample by use of NQR.

• Typically we have about 100 mg's of material.
• And the unfortunate thing is that most molecules have more than one (e.g. up to five) nitrogen atoms.

Do you see any prospects of your new instrument for such cases.

Kind regards

Alfred

Dear Alfred,

Our current sensitivity without optimization for 35Cl is 200 mg (see Fig 3 text under Fig 3). The biggest challenge will be to stabilize the temperature.

A dedicated 14N prototype is already in development. I will be talking to my team leader to get permission to request material samples for testing.

Regards,

Andrew

Have any of you been confronted with the issue of NMR testing dental ceramics or dental cements?

Dear Andrzej Pelczar ,

This is an area that is quite far away from me. But with the graviton approach, we have managed to understand what the boundary between micro and macro is, beyond which we will in principle be unable to go - the smallest wavelength of X-ray that we can technologically capture, to detect a change in its behaviour. In my opinion, the methods should be approached in this way. The starting point should be hydrogen because it is the simplest chemical element... and build your system step by step, including all the more stable or long decaying chemical elements... (which you have probably done)Your technology has great importance because it can be used for earthquake prediction... and prediction of other natural disasters.... If I'm wrong, feel free to correct me!

Regards,

Laszlo

https://authors.elsevier.com/c/1ilU2cPqbsgPv

The topic is a bit far from pharmacy, but are any of you involved in petrophysics?

https://link.springer.com/content/pdf/10.1007/s13202-022-01476-3.pdf

Thank you very much.

Surface nuclear magnetic resonance may potentially be used in oil industry (so far mainly for water content of soil analysis).

https://www.bruker.com/en/products-and-solutions/mr/nmr-food-solutions/honey-profiling.html