More recently, trigeminal nerve lesions related to multiple sclerosis found much attention.
In contrast, scarcely a report has focused on how MS affects posterior or anterior spinal nerve roots.
In the pre-MRI era, however, several post-mortem studies described how MS damages the spinal cord's nerve roots.
Please check Huber Oscar's Berlin thesis of 1894 "Zur pathologischen Anatomie der multiple Sklerose des Rückenmarks" and
Falkiewicz Tadeusz's paper "Zur Pathogenese der multiplen Sklerose" (Arb Neurol Inst Wien, 1926; 28:172)
Who seem to have given the best topical accounts.
Overcoming the given dilemma might help understand the disease process.
(Apart from exploring the MS-related periphlebitis retinae in closer detail)
I'd like to add to your question. An old cadaver study showed hypothalamic lesions in 16/17 MS subjects. (I personally think they just sliced the 17th too thick). We know thermodysregulation is nearly universal in MS. Is there a way to see MS lesion in the hypothalamus as well?
Thank you, Till-Karsten Hauser, for considering my uneasiness about the gap separating the post-mortem and MRI evidence concerning multiple sclerosis's spinal nerve root pathology.
Who might bridge the gap between the topical milestone papers from Berlin and Vienna referred to above and what is given in the potentially related MRI literature?
Do you know of anything that surpasses the conflicting assertions made in such papers as
Lane JI, Koeller KK, Atkinson JL. Enhanced lumbar nerve roots in the spine without prior surgery: radiculitis or radicular veins? AJNR Am J Neuroradiol, 1994,15(7): 1317-25, Kim DH, Cho JH, Mathieu Boudier-Revéret M, Chang MC. Gadolinium enhancement in cervical dorsal roots in a patient with acute autonomic and sensory neuropathy: a case report. BMC Neurology 2023; 23: 144, Tawa N,1 Rhoda A, Diener I. Accuracy of magnetic resonance imaging in detecting lumbo-sacral nerve root compromise: a systematic literature review. BMC Musculoskelet Disord. 2016; 17(1): 386?
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