Is there a substance that inhibits calcineurin?

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Maxime Gauberti

There are numerous calcineurin inhibitors including the clinically approved tacrolimus (FK-506), inhibitory peptides (ITSFEEAKGLDRINERMPPRRDAMP), Ascomycin (very similar to tacrolimus, bind to FKBP-12)... The right choice depends on your specific project: in vivo targeting ? in vitro ?

Good luck :-)

Teodoro S Kaufman

Tacrolimus. See Nature Clinical Practice Nephrology (2006) 2, 398

Mahadev Asaram Jadhav

plz try following inhibitors and confirm its inhibitory action against calcineurin.

INCA-6(CID:230748), AGN-PC-0HSVL2(CID:68238197), AC1MSASJ(CID:3581390)

Jennifer L Gori

Tacrolimus (FK506).

Indramohan Singh

See this article. Hope this helps.

http://www.australianprescriber.com/magazine/29/4/99/101

Christian Gabriel

Also check this one: http://www.ncbi.nlm.nih.gov/pubmed/19860902