Drug Bank and PubChem might be what you're looking for. They're useful for solubility and physical properties but less so for potency.

http://www.drugbank.ca/

http://www.ncbi.nlm.nih.gov/pccompound

Janet thanks so much! This helps a lot!

I always found the Merck Index to be useful. The link requires a subscription, but I imagine UMich has one.

Try the link again.

https://www.rsc.org/merck-index

That looks like exactly what I needed. Thanks!

Dear Olga,

You might also want to try the freely accessible Chemicalize.org that allows you to get the predicted logP value for any query compound along with several other useful information on their physicochemical properties (you can select the "All calculations" option to activate the detailed mode that show several properties like atomic charge, isomeric form, etc.). However, this tool does not provide any potency information.

http://www.chemicalize.org/

Additionally, you might want to check out ChEMBL that provides you with detailed potency information (putative targets) along with its corresponding properties (the typical rule of 5 properties like hydrogen bond donor and acceptor, molecular weight, etc).

https://www.ebi.ac.uk/chembl

Hi

you can find your answer in chemspider website which contains very useful information about physicochemical properties of drugs and fine chemicals.

I've used The Handbook of Chemistry and Physics on occasion.

Thanks so much!