Yes. The inflammation response of the immunity system should be perceived as the sixth sense in fighting with tumor:

Article Immunity, Inflammation, and Cancer

Inflammation is also an indicator of over-nutrition and suppression of autophagy:

Article The Roles of Autophagy in Cancer

So daily strategic under feeding should be able to maintain the normal functioning of autophagy in the body and effectively clear the initiation of tumor at the beginning.

DearLigen Yu

Yes, inflammation is a set of factors that help the organism invaded by neoplastic cells to stop its advance; it is the first line of containment. In this line of research and thinking, it is found what can be a sixth sense in the cell to detect changes adjacent to its membrane and that could potentially be harmful.

Thank you for the links to be more informed in relation to the pathophysiology of inflammation as part of non-specific cellular and humoral immunity, mediated by interleukins and interferon-like proteins and trace elements. Likewise, the role of specific malnutrition or undernutrition, as a limiting factor for cancer growth at first, through stimulation of autophagy.

Dear all

When neoplastic cells proliferate to a certain critical point in a single site, they tend to leave the agglomeration (tumor), escaping and looking for other organs or tissues to settle in, causing metastases; The same happens with normal cells, which when "feeling crushed" in a place crowded with foreign cells and in large numbers (neoplastic), through their membrane receptors produce interleukin-like mediators that call NK cells and stimulate macrophages and T lymphocytes to activate the first line of defense against invading cells, whereupon the attack begins with antibody opsonization and phagocytosis.

José Luis

Interesting subject

Following the same speech, I comment on the following:

• It seems that cell membranes have a sense similar to touch, but for internal sensations (propioception).
• This sense, when the cell perceives it through cellular receptors, triggers biochemical mechanisms that function as mediators.
• These biochemical mediators are remote messengers that stimulate other cells that respond in a similar way, creating a network of responses.
• Final result, biochemical stimulus to attract cytokines and inflammatory cells to defend normal cells from invasion by foreign cells, eg tumor cells.

regards

José Luis

Dear Hassan Izzeddin Sarsak

Integration at the cellular and biochemical-molecular level starting from their membranes and the intercellular-interstitial space with biochemical mediators that exist in said site.

regards

José Luis

Dear all

In biomedical research, a special sense of cells has been identified, which allows them to escape from a site that is very full of cells or "crowded", which happens with both normal and tumor cells.

This mechanism of cellular escape from one crowded cell site to a less populated one is what researchers have termed the "sixth sense." Mechanism that we could explain as proprioception of the cell membrane, which when feeling the contact of other (many) cell membranes feels the equivalent of a "pinch", which stimulates the synthesis of interleukins and other factors that allow it to "move" and move away from that site to a more cell-free site.

If the phenomenon occurs between normal vs metastatic neoplastic cells, we could say that this "sixth sense" allows them to escape and at the same time produce substances called interlecuins that would activate the capacity to destroy malignant cells through phagocytosis of macrophages, polymorphonuclear leukocytes and lymphocytes. . Likewise, the activation of both B lymphocytes for the production of antibodies and T lymphocytes that together would integrate a Th1-type immune response.

If the phenomenon occurs between neoplastic cells in situ (primary tumor), when the tumor mass reaches a very large number of these cells and the tumor increases in size, it will have difficulty to continue reproducing and obtaining nutrition through the capillary circulatory system. Result, malignant cell survival, with the release of neoplastic cells via lymphatic and arterial vessels to invade other tissues at a distance, which is technically called metastasis.

As can be seen, said protection mechanism or "sixth sense" is like a two-sided coin, one with positive or beneficial effects for humans, and the other, deleterious or malignant, as it indicates an aggravation of a neoplastic disease such as cancer.

However, the identification of these mechanisms of cellular and humoral immunity; one protective and the other harmful, creates the first section of a path or line of research to find a way to strengthen immunity against malignant tumors with actions, substances or interventions to positively feedback these changes in normal cells in order to increase their defenses like phagocytosis of tumor cells; or stimulate the apoptosis mechanism in these cancer cells (programmed cell death).

The other pharmacological, biochemical or inventive intervention; it would be to directly stimulate apoptosis in neoplastic cells. In this regard, there is an experimental substance derived from marijuana, cannabinoids (cannabidiol) that stimulates specific receptors on the tumor cell membrane, stimulating apoptosis. Through this experimental pharmacological effect in cancer patients, partial or total remission of their condition has been achieved, especially in patients with end-stage metastatic renal and lung cancer.

regards

José Luis

https://www.catalunyavanguardista.com/el-sexto-sentido-de-las-celulas/

https://medicalxpress.com/news/2020-10-cancer-cells-crowded-tumors.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

https://www.cancer.gov/espanol/cancer/tratamiento/mca/pro/cannabis-pdq

Complete information on this mechanism and new sense of proprioception at the biochemical and cell membrane level, you will find it in the following links:

1. El ‘sexto sentido’ de las células. Catalunya Vanguardista. Digital Independiente. 16 octubre, 2020 https://www.catalunyavanguardista.com/el-sexto-sentido-de-las-celulas/

2. St. Anna Children's Cancer Research Institute. How cancer cells escape crowded tumors. MedicalXpress. Oncology & Cancer.Immunology.october 19, 2020. 2. https://medicalxpress.com/news/2020-10-cancer-cells-crowded-tumors.html?utm_source=nwletter

It is possible that some people have a subliminal heightened proprioceptive or olfactory awareness of cancer etc. even though they don't recognize it as such. Dogs are alleged to detect cancers with a high degree of accuracy:

• https://www.sciencedaily.com/releases/2019/04/190408114304.htm
• https://edition.cnn.com/2015/11/20/health/cancer-smelling-dogs/index.html

Dear Karl Pfeifer

Indeed, the smell of dogs can identify aromas, especially amines (accelerated metabolism and catabolism within the same tumor) in cases of cancer, even in the initial stages. Research continues to standardize this information and establish the most suitable type of dog breed for this purpose.

regards

José Luis

According to the information provided by K. Pfeifer, so far the diagnostic accuracy of the smell of dogs in cancer is very high, 97%, identifying the aroma in the breath of people. Studies have been carried out with different types of cancer, the most studied being the "breast cancer".

José Luis

In the same sense of the speech, mention the following:

• In general, the volatile products emanating from tumors are organic substances, some of them, as I said before, are amines.
• The dogs with the greatest olfactory power are the cross between a Labrador Retriever and a Spaniel; although all dogs can be trained as "cancer sniffers".
• Depending on the organ affected by cancer, it is convenient to sniff a special type of sample; urine for kidney, prostate, bladder and urethral cancer. If it is skin, the "direct sniff" of a suspicious area of skin (macula, ulcer, fast-growing lentigo, etc.).
• If it is from the oral cavity, respiratory tracts (larynx, trachea, lungs) in saliva and breath sample.
• In all metastatic cancers, direct inhalation (sniffing) of skin, breath, urine, saliva, and blood.

regards

José Luis

Hi all

Science and the results of biomedical research are linking like a chain the links of partial knowledge in a particular field, the pathophysiology and immunopathology of cancer. In this regard, it has been observed that mature and senescent cells are more rigid than young ones and that when they agglomerate in the proliferation process due to normal development or by duplication due to repair due to tissue damage, the proprioception of the membrane is activated cellular, the "sixth sense" mentioned above.

Furthermore, relative to immature cells during the duplication process, these cells become more flexible and malleable, which helps them find a place in less populated tissue sites. In addition, this property allows you to guide your development by looking for these gaps.

https://phys.org/news/2020-11-scientists-tissue-tension-cell-division.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

regards

José Luis

I think that

Dear Dunya Mohamed Hameed

Thanks

According to the latest biomedical research on the pathogenesis of neoplastic diseases, some interesting evidences have been identified for reflection and future diagnostic and therapeutic decision-making in this regard; among them, the following:

• Apparently, there is a sixth sense that in phenomenological terms has been called deep proprioception, which corresponds to the "conscious" sensitivity of the functioning of internal organs (Visceras for example), which is generally unconscious, but emerges to consciousness in case of abnormal function or tissue damage.
• In the case of the development of neoplastic diseases, we know more and more. The onset or early stage of a neoplasm has been identified as vesicles containing within them one or more neoplastic cells that circulate in the bloodstream and generally undetectable in general laboratory studies.
• After a certain time, these vesicles accumulate in tissue territory with an apparently positive tropism for certain signals that guide the implantation of the "nest with undifferentiated neoplastic cells".
• These anaplastic and dysplastic cell nests trigger their multiplication to form micro nodules that, through certain biochemical signals (angiogenic vascular growth factor), stimulate the formation of blood vessels that supply the nascent cancer tumor.
• With time (weeks, months or years) the tumor nodule is already visible and sometimes detectable by medical examination and laboratory and office studies oriented according to specific symptoms or syndromes and for neoplastic identified in the patient.
• At this time, often medical, surgical and cancer treatments; they have a limited resolutive effect, due to the great growth of the cancer and its local invasion to the adjacent tissue and distant metastasis via lymphatic and blood.
• Throughout this neoplastic process from implantation, nesting, local tumor growth and distant metastasis; Biochemical and apparently cellular and molecular proprioceptive phenomena have been identified, which guide the growth path and disordered survival of cancer cells.
• These changes have been termed pathophysiology mediated by "a cellular proprioceptive sixth sense." Same sense that allows the contact between membrane and membrane of neoplastic cells that are tolerated to a certain extent to grow agglomerated without invading the interstitial space that belongs to each one; and at the same time, inhibiting the mechanical defenses of the tissue until now healthy or undamaged, allowing it to be invaded by foreign cells.
• Among themselves and within each conglomerate of anaplastic-dysplastic cells, when they are in rapid reproduction and growth, the microcirculation stimulated by angiogenic tumor growth factor detects small or atrophic neoplastic cells, which are phagocytosed by the larger and strong of them, serving them as food; a situation that is stimulated when they are under the effect of some antineoplastic treatment and inhibition of tumor vascular growth.

All of this seems unreal or fantastic, but there is already enough cellular, tissue and biochemical evidence to support these conjectures.