Is there a proven way to reverse the cross- linking of long term formalin fixed tumors for western blotting?

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Valeria Tananska

Yes, there is. More info here:

Article Proteomic developments in the analysis of formalin-fixed tissue

Article Successful Protein Extraction from Over-Fixed and Long-Term ...

Article Quantitative protein analysis from formalin-fixed tissues: I...

A generally useful article:

http://www.jbc.org/content/279/8/6235.long

I hope this helps :)