Is there a pharmaceutical form in the form of granules melt on the skin as alternatives to ointments and creams?
And why there is not despite the high absorption of the active substance in the drug and its full access to the side effect in this pharmaceutical form ?
to the very best of my knowledge, an manufacturer aims for predictable resorption (or not, depending on the intention of the drug, eg. transdermal opioids vs corticosteroids in dermal applications)
Hello
Yes there is pharmaceutical solid dosage form as powder easily penetrate skin and absorb by epidermis as nanoparticle, user they can able to put on skin by simple move finger on the powder penetrate skin. is more better than ointment may ointment need some time to absorb and remain greasy on skin. some cosmetic company they are using as filler and Botox. this nano particle is alternative ointment and cream.
Big particle can not penetrate epidermis if you can add penetration enhancer carrier may be helpful novel types of macromolecular penetration enhancers, such as anionic polyacrylates and cationic chitosan and chitosan derivatives, may help full.
Hi Ahmed,
The breakthrough technology of nanoparticles have added a lot to topical drug delivery dosage forms. Please refer to the following link:
https://www.google.ae/url?sa=t&source=web&rct=j&url=http://opus.bath.ac.uk/17561/1/Accepted_version.pdf&ved=0ahUKEwisr_mX2bLTAhVFvBQKHWuzDM8QFggpMAI&usg=AFQjCNFlBOdR2KEqvn6x7Hi77Nf9qkxLcw&sig2=dXlBOu0s1kGbjWmeKkBDgA
Regards,
Dr. Rayes
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