Knowledge of the properties of drugs as inhibitors or inducers of the eight kinds of P450 cytochromes is well established. For the interaction of herbals or nutrients with the P450 system in the liver I found only some examples. In treatment with immunsuppressiva in the case of transplantation of organs the patients often don´t know something about these interactions and get problems with the dosage of the taken immunsuppresssiva. An example is the inhibition of the CYP2D6 by consuming ginger roots, cinnamon, ginseng or grapefruit.
Hello my friend,
this web site can be of a great help:
http://livertox.nih.gov/
It is a database of all herbs, supplements, drugs that can interact with the liver and its enzymes. Plus, it contains some clinical cases, if a herb or supplement has shown hepatotoxicity. One interesting case is the case of Noni juice where 3 people have shown hepatitis due to Noni consumption.
I am working on it... big job. Free access to health practitioners and researchers:
www.herbdrugnutrient.com
There are handbooks or compendia in both sides of the Atlantic listing also herbal-associated interactions with CYP enzymes. Much data exist on in vitro interactions, but what is their value in extrapolation to the in vivo situation is debatable. I can search some recent sources of information if needed.
Olavi Pelkonen ([email protected])
You might be interested in this review:
Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):359-77. doi: 10.1517/17425255.2014.873786. Epub 2014 Jan 6.
Drug interactions with phytotherapeutics in oncology.
Haefeli WE, Carls A.
PMID: 24387348
You may be interested in this paper by a colleague of mine:
Lim, S. T., Dragull, K., Tang, C. S., Bittenbender, H. C., Efird, J. T., & Nerurkar, P. V. (2007). Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats. Toxicological sciences, 97(1), 214-221.
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