Respected Ashraf Sir

We can use SwissADME which is free and online tool. We just have to submit list of our molecules (drugs) in SMILES format.

Prediction of biological activity of small molecule could be achieved by several approaches such as inverse molecular docking , pharmacophore mapping and network pharmacology, these 2 online servers could be helpful

1-http://lilab.ecust.edu.cn/pharmmapper/index.php

2-http://sea.bkslab.org/

Dear our respected Professor

Swiss Institute of Bioinformatics provide a good picture for the prediction of the most probable drug targets. i have tried :Swiss target prediction"

http://www.swisstargetprediction.ch/

in addition, other tools such as Swiss docking, similarity search and Swiss ADME could be helpful

also Molinspiration (a free web software) could also help

http://www.molinspiration.com/cgi-bin/properties

this software was cited in many publications with good IFs