In the case of amino acids such as Asp and Glu, it is generally known that the charge state can change due to protonation when exposed to the acidic pH in the endosome.
(e.g. DT toxin - TL5 loop (E349, D352))
However, the pH of endosome is about 5~6 while the pKa of Asp and Glu is about 3~4, so I think it will still be a little difficult to be protonated.
However, I remember seeing the literature that the location immediately adjacent to the membrane has a lower pH than the endosome lumen, making Asp and Glu more easily protonated. But I can't find any reference for this, so I'm asking your help.
Can you let me know if you have any information about the literature related to this?
Thank you!
- Badges
- Science topic
- Similar topics
- Engineering
- Petroleum Engineering
- Gas
More Daeseong Kim's questions See All
Similar questions and discussions