The answer depends on what you mean by "reliable", and whether you are searching for a general answer or are looking at one specific situation.
To my knowledge, the MIRD formalism will describe quite precisely the absorbed dose in target organs for known activity in the source organ(s), for standard geometries. Deviation from standard geometries will make the prediction less precise. More uncertainties will be introduced by the description of distribution and retention of the radiopharmaceutical within the different body tissues. You will have to check the MIRD documents and other relevant literature to get more detailed information on the case you are interested in.