Molecular wet of stigmasterol is 412.69; clogP value =7.89;Solubility = -6.44;Drug Likeness value = 1.22; Drug score value = *0.19 although it can not cross the blood brain barrier as i am using it for primary neuronal culture.
I did a quick search on stigmasterol and I see no reason why you should not call Stigmasterol a drug candidate for CNS. There are many studies implementing it in neuronal function. There are many other drug CNS drug candidates out there that do not cross the blood brain barrier.