Is estimating serum BDNF (Brain Derived Neurotrophic Factor) a valuable marker in neuro-degenerative diseases like Parkinson's as compared to central BDNF expression mapping?
actually in some relevant article i saw that they measured serum BDNF
In attached files you can see some of this articles
Article Serum brain-derived neurotrophic factor response to aerobic ...
Also this article
Article Effect of six weeks of endurance exercise and following detr...
Thank you for the articles, though they are on metabolic syndrome and MS. I actually plan on working on Parkinson's and have quite a few articles in relation to bdnf. Some published work says that serum bdnf is valuable marker for brain plasticity few others refute the same. So am still confused about the relation between serum bdnf and brain bdnf.
I think that this article are usefull
also this abstract
Serum BDNF Levels In Patients With Parkinson's Disease: Correlation With Specific Cognitive Parameters
Granholm , L., Turner , T., Boger , H., Hinson , V.
Charleston, SC, USA
Objective:
To determine whether serum BDNF levels correlate with specific cognitive tasks in Parkinson's disease (PD) patients with executive dysfunction.
Background:
Previous research suggests an association between serum levels of Brain-Derived Neurotrophic Factor (BDNF) and cognitive functioning in PD. However, relationships between BDNF and specific aspects of executive functioning and memory in PD remain unclear. The aim of the present investigation was to explore these relationships more closely.
Methods:
Patients with idiopathic PD with cognitive concerns in a university hospital movement disorders clinic were referred for clinical neuropsychological evaluation. These patients were also invited to participate in the study. Exclusion criteria included diagnosis of dementia, history of surgical intervention, and co-morbid neurological illness. A total of 23 patients consented to participate and were included in the study. Blood serum was drawn during the clinic visit. BDNF levels were examined using an R&D ELISA kit according to the manufacturer's instructions. Comprehensive neuropsychological evaluation was performed during a later visit, and the examiner was blind to participation status. Pearson product-moment correlations between BDNF and cognitive measures were examined.
Results:
BDNF was not strongly related to global cognition (Mattis DRS-2, r=.17). However, BDNF levels showed relationships to measures more sensitive to PD executive dysfunction, including delayed verbal recall (CVLT-2, r=.31) and set-switching (Fluency Switching: r=.40; Trails Switching: r=.52). These data suggested a relationship between lower BDNF levels and worse performance on neuropsychological tests that measure executive dysfunction.
Conclusions:
Serum BDNF levels appear to correlate with executive functioning and memory in non-demented PD patients. These findings suggest potential clinical and research utility of serum BDNF assays in tracking cognitive functioning in PD.
To cite this abstract, please use the following information:
Granholm, L., Turner, T., Boger, H., Hinson, V.; Serum BDNF levels in patients with Parkinson's disease: Correlation with specific cognitive parameters [abstract]. Movement Disorders 2013;28 Suppl 1 :542
Article Serum levels of brain-derived neurotrophic factor correlate ...
Has anybody observed 20-22 kdA BDNF band along with 14kda mBDNF, 28 kDA truncated BDNF and 32 kDA Pro-BDNF? What is this 20-22 kDA BDNF band?
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