On one hand, most foreign proteins are immunogenic. On the other hand, serum albumin is highly conservative and it has similar structure in different species. So if we inject a mouse with HSA or BSA, will it cause an immune response? How severe will that response be?
Aitsana Maslakova
Of course it will. You will introduce a foreign protein of a relatively large size. If you have any doubt, check the cross-species alignment and analyse the accessibility of distinct regions on crystal structure if available. What I can state for sure (basing on the own experience), rabbits have immune reaction toward human albumin.
Good luck!
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