In the age of Mutiresistant drug bacterium(s) and eukaryotic pathogenic organisms or superbugs, we are in a constant lookout for new treatments and especially antibiotic drugs. Two approaches, in particular, have been given a lot of attention, i.e.., Phage therapy and antimicrobial peptides, etc. Antimicrobial peptides are compounds produced by all eukaryotic lifeforms and may serve in every line of immune defense. But they are not living systems and are biochemical compounds. Therefore are subjected to resistance and increased allergenicity by virtue of their quaternary, tertiary or point of origin, and subjection to the subject (i.e.., treating humans or animals with a plant AMPs).
So are AMPs worth it? (in comparison to the phage therapy)
I'm quite new to the field with a basic level of understanding. I hope researchers with expertise or Good knowledge will be able to answer this question.
Thank you
Check this work out- https://www.researchgate.net/publication/342821777_The_value_of_antimicrobial_peptides_in_the_age_of_resistance?_sg%5B0%5D=W9xauZG3ZhbjcMjXHuj18RZVFQF04j88G4QV1Xgq1wbRYljaDVLg9Kt4iBhCzEUUKkl7bHFRGBspZRrgFxStO-aAJo9VS90U8anQdhBy.V9IZsofACQ85Lx14SMJEuWyaa5OhtJLNp_e_LwlWmuA70Elof1tf6n4pn3IG41Jmoniw-S-_LOAVsWKd0AlJEw
Yes, I think it's a hell of a good work. Currently, peptides are being used and frequently studied as a main form in nano-particulate drug delivery system which becomes a best therapeutic option in overcoming drug resistance and efficacy problems posed by conventional drug therapy. So, I strongly think it's vivid work.
Certainly, its worth to work in this area. The quest to search for new antimicrobial agents is continuous process and if they are peptides of plant origin then safety issues will also be less. Since, there activity is known from plant, synthesising them and also modifying to increase their potency, followed by screening and evaluation is worth area to work.
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