Hi, I would like to ask whether a placebo + active control arm is still considered a placebo. In dentistry, scaling and root planing is considered an active control. There are studies especially drug trials that have 3 arms: 1) active control 2) placebo + active control 3) treatment + active control (eg. https://www.ncbi.nlm.nih.gov/pubmed/21687979). therefore, which arm should I drop to include in a pairwise meta-analysis? or do I equally split the treatment group?
Thank you for your time.
Dear Oi Leng Tang,
The combination of the two techniques is used and in some cases it is necessary, however in other cases it is not desired at all to use them. Please see the links and attached files.
https://www.amazon.fr/Bipolar-Book-History-Neurobiology-Treatment/dp/0199300534
https://training.cochrane.org/handbook/current/chapter-11
Article The Impact of Excluding Trials from Network Meta-Analyses – ...
Article When a Placebo Is Not a Placebo: Problems and Solutions to t...
Article Sensitivity to Excluding Treatments in Network Meta-Analysis
Article Interpreting Indirect Treatment Comparisons and Network Meta...
Best regards
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