What is probability of transmission of Parkinson's disease from parents to offspring's?
Approximately 15 percent of people with Parkinson disease have a family history of this disorder. Familial cases of Parkinson disease can be caused by mutations in the LRRK2, PARK2, PARK7, PINK1, or SNCA gene, or by alterations in genes that have not been identified. Mutations in some of these genes may also play a role in cases that appear to be sporadic.
Among familial cases of Parkinson disease, the inheritance pattern differs depending on the gene that is altered. If the LRRK2 or SNCA gene is involved, the disorder is inherited in an autosomal dominant pattern, which means one copy of an altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition.
If the PARK2, PARK7, or PINK1 gene is involved, Parkinson disease is inherited in an autosomal recessive pattern. This type of inheritance means that two copies of the gene in each cell are altered. Most often, the parents of an individual with autosomal recessive Parkinson disease each carry one copy of the altered gene but do not show signs and symptoms of the disorder.
When genetic alterations modify the risk of developing Parkinson disease, the inheritance pattern is usually unknown.
Approximately 15 percent of people with Parkinson disease have a family history of this disorder. Familial cases of Parkinson disease can be caused by mutations in the LRRK2, PARK2, PARK7, PINK1, or SNCA gene, or by alterations in genes that have not been identified. Mutations in some of these genes may also play a role in cases that appear to be sporadic.
Among familial cases of Parkinson disease, the inheritance pattern differs depending on the gene that is altered. If the LRRK2 or SNCA gene is involved, the disorder is inherited in an autosomal dominant pattern, which means one copy of an altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition.
If the PARK2, PARK7, or PINK1 gene is involved, Parkinson disease is inherited in an autosomal recessive pattern. This type of inheritance means that two copies of the gene in each cell are altered. Most often, the parents of an individual with autosomal recessive Parkinson disease each carry one copy of the altered gene but do not show signs and symptoms of the disorder.
When genetic alterations modify the risk of developing Parkinson disease, the inheritance pattern is usually unknown.
Richard Myers from the Boston University School of Medicine has done extensive work on familial Parkinson's disease.
https://www.researchgate.net/profile/Richard_Myers
It's only in around 10% of the cases. And, it present at younger age than the sporadic ones.
Dear friend,
Greetings.
Still the etiology of PD is under research. Consensus study reveals that 10 to 15 percent chance is there that the successor may have the disease.
I have done some work on Parkinson's disease and published also.
I hope this helps you.
Best regards
Dr.Indrajit Mandal
I have got two families who are showing symptoms of Parkinson in AD way. They have symptoms in their early age and symptoms start appearing between 30-40 years.
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