I am trying to improve the functionality of PLGA scaffolds by performing different types of pretreatment using wet chemical technique. In literature, most of the articles use NaOH rather than HCl for PLGA scaffolds pretreatment. Could you please provide me with more data or if there anybody that has already done a comparative strategy for this regard for scaffold functionalization purpose ?
General considerations without specific PLGA considerations:
With basic treatment, you only cleave ester functionalities, so you shorten your PLGA chains and open functionalities for other reactands.
With acid treatment, both ester cleavage and ester bond formation may happen, so if a random chain length change is desirable for your aspired functionality, acid treatment is your go-to tool.
Jürgen Weippert Thank you for your reply. Actually I am looking to functionalise the PLGA scaffolds with bioactive molecules. Indeed, according your answer, you suggest that I use basic treatment rather than acid one. Thank you again. If there any publication so far about these treatments that you kindly can provide me ?
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