Hi Vincent,

good question, but I don't know the answer. Perhaps Jolita knows?

Gertjan

from what I have seen , the answer is no in the adult mouse if aging is not associated with liver injury. Then I would say depending at what genes you are looking at, If you are looking at the glucose metabolism or lipid metabolism I would not be surprised to see some of them slightly altrered by the age in their pattern of expression from the periportal to the periveinous area, these patterns could be maybe a bit less restricted and also in this case the nutritional status could be key.

Just to be clear in regards to my previous answer, what I meant is some enzyme could maybe a some increased or decreased expression on their opposite side (veinous vs portal) but overall i don't think that liver zonation is altered.

Hello

Yes i agree withe Pascale Bossard . these links may help you 

Good Luck 

http://onlinelibrary.wiley.com/doi/10.1002/hep.21082/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093700/

https://www.ncbi.nlm.nih.gov/pubmed/8344416

We have previously studied about the tissue region differences in the rat (please see file; J Chrom B rat BIN LIP Km).   Skin, stomach, gut, cerebrum, and pancreas have shown the tissue region differences, but liver and kidney (left and right) may not show the tissue region differences.   

By the way, development or ageing of human livers is interesting phenomenon to me and to every biochemical researchers (please see file; HepG2 fucoidan).

Amended on 06 March 2017

Since the tissue region differences are absent in the rat livers, the development or differentiation of human cultured-liver cells are investigated.   Liver cells differentiate in their proteins in accordance with the ageing, and the results are summarized as follows.   Protein concentration has been expressed in μg/mg of cell protein. 

Representative changes are as follows; i.e.,

                             Fetal Hc                                  Adult cured HepG2

Apo B-100                 0.0                                              29.7                                             

Apo L-I                      0.0                                               4.9 

LDL receptor            0.0                                                4.0

Albumin                   0.0                                                5.5

Connectin/titin         0.0                                                16.6

Serine-type Lipoamidase/cholesterol-esterase  (please see file; Hui lipase)        

                                0.0                                                12.8

Thiol-type Serum biotinidase/lipoamidase/enkephalin-aminoexopeptidase

                                1.8                                                 9.5

Ceruloplasmin         2.3                                                43.3

α-Fetoprotein           2.3                                                 5.3

Transferrin              9.9                                                12.3                      

HbA                         4.8                                                0.0

Thus, we have declared that HbA is serum marker of child and Connectin/titin is serum marker of adult.    

Fetal-liver normal-hepatocyte cells (Hc; age -1y) have following proteins; i.e.

1. Histone H 3.1　　　　　　　　　　　                                                   46.7

2. Protein kinase C eta type                                                          40.2

3. Actinin-associated LIM protein/PDZ and LIM domain protein 3/ Alpha-actinin-2-associated LIM protein                                                             28.5

4. Protein FAM8A1/Autosomal highly conserved protein               27.5

5. Plant proteins of Arabidopsis thaliana (thale cress)                            27.3 

(Biotin synthetase and Isovaleryl-CoA dehydratase)   These mitochondrial genes may be of humans. 

6. Plancental-specific 1-like protein/Placenta-specific protein 1        24.4

7. Protein SCD6 homolog/Protein FAM61A      　                             　20.1

8. Desmoyokin/Neuroblast differentiation-associated protein AHNAK   19.9

9.  Cytochrome c oxidase (Complex IV) subunit 2                               18.0

10. Mitochondrial chaperon BCS1 (for assembly of Complex III)       16.8

11. Dyslexia susceptibility 1 candidate gene 1 protein                           16.2

12. Protein SSX8/Synovial sarcoma, X breakpoint 8, isoform CRA_a    15.8

12. RWD domain-containing protein 2A                                                    15.8

14. Lipoic acid synthetase (Lesionella pneumophila or mitochondria)  15.0

 15. Neutrophil NADPH oxidase factor 4/Neutrophil cytosol factor 4          14.6

 16. Histone deacetylase 4/HDAC4                                                          14.2

17.  Nardilysin                                                                                           14.0

18.  Notch homolog 2 N-terminal-like protein                                             13.4

19.  Protein regulator of cytokinesis 1                                                      13.1

20.  Glutathione S-transferase A4/GST class-alpha member 4               12.9

This result suggests that the development and/or differentiation requires very much energy from mitochondria.

Healed HepG2 cells (with fucoidan treatment for 3 days; age 15y; putative normal state) have

1. Mucin-16/Ovarian cancer related tumor marker CA125                    67.4

2.  Ceruloplasmin                                                                                   43.3

3.   Apolipoprotein B-100/Apo B-100                                                      29.7

4.   Histone Hs                                                                                           25.1

5.   Semaphorins                                                                                      17.2

6.   Connectin/Titin                                                                                16.6

7.    Cadherin EGF LAG seven-pass G-type receptor 1/Flamingo homolog 2                                                                                                    14.5

8.    Probable ATP-dependent RNA helicase DHX37                              12.8

8.    Lipoamidase                                                                                           12.8

10.  Transferrin                                                                                              12.3

11.   Laminin subunit alpha-2                                                                11.5

12.   Insulin-like growth factor II receptor/IGF-II receptor                      11.3

13.    Deubiquitinating enzyme 19                                                           10.7

14.  　DNA polymerase kappa                                                                 10.4

15.  　Stabilin-1/Fasciclin, EGF-like/laminin-type EGF-like and link domain-   containing scavenger receptor 1                                                            10.1

16. 　Human serum biotinidase (our sequence)      　　　　　　　　　　　　　 9.5　　

17.   [F-actin]-methionine sulfoxide oxidase MICAL1/Molecule interacting with CasL protein 1/Enhancer of filamentation 1                                     8.4

18.  Protein KIAA0423/Crescerin-1                                                        8.2

19.  Protein KIAA1199/Cell migration-inducing and hyaluronan-binding protein                                                                                    7.9

20.  U4/U6.U5 tri-snRNP-associated protein 1/Squamous cell carcinoma antigen recognized by T cells 1                                                                     6.6