We know transfer learning is used immensely now a days. Shall we use a model trained on coco dataset for cancer detection.?

The answer is Yes. The cancer images eg: histopathology images are entirely different from coco dataset images like cat,, dog, van etc. As the coco dataset features are also different from cancer...

15 December 2020 2,625 5 View

What is the importance of segmentation of histopathology images prior to classification?

I wanted to know how a classifier model will be affected by a poorly segmented image?

21 September 2020 8,205 14 View

Can we extract toxins from the media or the substrate it is growing in?

Actually these are two separate questions: i. How to extract mycotoxins from the media PDA the fungal culture is growing on? ii. Can we extract the toxin from the natural media it is growing on?

06 September 2020 8,193 5 View

I have two H and E stained histopathology image datasets of breast. I wanted to use both for training a single algorithm. So how can i do this?

Should I combine both the datasets and train the ML algorithm or should I need to train the algorithm separately with the datasets and test on a single set.The test set is the combination of both...

08 May 2020 6,648 5 View

I carried out patchdoc for Protein-DNA and got the result but i need a tool for find interaction energy

10 July 2017 9,029 2 View

We are having trouble with loosing the top of some of our lanes on SDS gels. Any ideas why?

28 September 2016 6,809 6 View

I would like to grow Arabidopsis using hydroponic method. Can anyone suggest a growth medium.

I need to test the concentration- dependant uptake of nanoparticles. Can anyone give different options for hydroponic medium (both commercially available and composition for medium)

30 June 2016 1,120 2 View

Job getting aborted due to errors in abaqus?

While running a dynamic explicit analysis in abaqus, job is getting aborted after a total time of 0.17seconds (after 2 to 3 hours of running). The model includes a soil slope, a pile with 0.25m...

01 June 2016 4,366 14 View

Soil-pile interaction-job aborted due to errors in abaqus ?

03 May 2016 9,794 3 View

Any substitute for raffinose during galactose induction?

Hi everyone, I am trying to induce the expression of a gene with a toxic product, under GAL promoter. I came across some threads about adding raffinose in the media during induction. Can this be...

23 April 2016 5,410 3 View

How to make ROC plot for the validation of ligand-based-pharmacophore models in discovery studio?

Hello, I already made a ligand-based pharmacophore by utilizing 60 dataset compounds by catalyst module in discovery studio. But I want to explore the ROC curve of that pharmacophore in order to...

02 March 2020 9,044 5 View

Database for pharmacophore based virtual screening?

Hello, Please tell me the database other than zinc, from where i can download the natural products subset of database in sdf format. Moreover, if any one has the conformational database for FDA...

05 June 2019 2,070 4 View

What is the 1% Enrichment factor in virtual screening?

I have developed a set of hypotheses using shrodinger's Phase algorithm. One of the values returned for each hypothesis is 1%EF. What does this value mean and how do I interpret it? The other...

06 July 2018 6,860 0 View

I have a work that I use Ligandscout version 3.1, could I publish it?

Hello everyone, I have prepared a pharmacophore model using ligandscout software version 3.1 and I want to publish this work, could I publish it? If yes, any suggestion about journals how could...

03 April 2018 2,160 2 View

How can I validate a pharmacophore from a target that does not have ligands described?

Hello. I have the following problem at hand: I need to validate a pharmacophore of a regulatory factor. There are no inhibitors described either for my target or for analogous structures. The...

02 March 2018 8,018 4 View

Is there any software free available to represent different fragments in pharmacophore like HBD,HBA, VdW region, hydrophobic region ?

Please sent me link of software free available for this purpose

01 February 2018 3,760 5 View

No title

11 December 2017 6,419 4 View

Pharmcophore

04 May 2017 4,582 3 View

What is the best way to construct a pharmacophore model?

If we encounter a situation, where one can construct a pharmacophore model via multiple-complex based as well as via Molecular dynamics based. What is the best way to proceed further and which one...

12 January 2017 8,137 9 View

Molecular Dynamics based Pharmacophore modeling?

What should be the appropriate time of simulation run and the criteria for the selection of time interval in order to extract the trajectory for the construction of molecular dynamics based...

03 January 2017 7,751 9 View