Life, by definition, is capable of growth, reacting to the environment, and metabolizing. So a spore, which has nearly no metabolism, will eventually react to the environment (say the presence of water) and grow, so it is clearly alive. I am not aware if that spore contains it's own water, and if it dries out completely, it would die, but that seems possible to me.
But there is no reason to believe that water is the only chemical that can be the basis of life. While we are searching for 'Goldilocks Planets' based on water, and not, say ammonia, it is not impossible that we would someday find something that displays all the hallmarks of being alive that is without water.
It is said that water is life and that there can be no life without water. Our own bodies are about 70% water and the brain itself is more than 85% water. Water is needed for primary production-photosynthesis which provides food to higher organisms like animals..it is needed for plant growth..for food..for everything. And this is why only the earth contains life. It is known as the blue planet---because it is the only planet that contains water and is capable of sustaining life.