Is IVS 1-5 (G-C) mutation in beta globin gene causing b-thal present phenotypically beta 'zero' or beta 'plus' type? please provide references on heterogeneity of clinical presentation in IVS-1-5 (G-C) homozygote or double heterozygote phenotypes. Our point of interest is whether the clinical presentation of Double heterozygote for HbS / IVS-1-5 (G-C) are heterogenous or not!