I think you can do v-fold cross-validation in GeneXproTools. Dr. Ferreira mentions in his answer to a similar question in one of the gepsoft forums that they have automated this whole process with GeneXproTools 5.0 MR2.

He describes how this can be done for Regression, Classification and Logistic Regression in the Knowledge Base. Follow any of the three links below for a detailed description on Cross-validation in Regression, Cross-validation in Classification, and Cross-validation in Logistic Regression:

http://www.gepsoft.com/GeneXproTools/Regression.htm#CrossValidation

http://www.gepsoft.com/GeneXproTools/Classification.htm#CrossValidation

http://www.gepsoft.com/GeneXproTools/LogisticRegression.htm#CrossValidation

Please see the blog post on Bootstrap Cross-Validation also for details at http://www.gepsoft.com/blog/bootstrap-cross-validation.

I hope this is what you are looking for.

Thank you.