Is there any data regarding the toxicity of clays as zeolite when used through the intravenous route? if there is known toxicity ... what is its mechanism?
Dear Amr,
Your question legitimate. To my knowledge No study has been done to determine the toxicity of zeolite clay in blood stream. However the following review article may give you some background on this interesting topic:
Chapter 7 - Toxicity of Silica Nanomaterials: Zeolites, Mesoporous Silica, and Amorphous Silica Nanoparticles
CHAPTER in ADVANCES IN MOLECULAR TOXICOLOGY 4:223-266 · DECEMBER 2010
In this chapter, an overview of the toxicity of silica-based nanomaterials is presented. Porous materials, such as crystalline, microporous zeolites, and mesoporous silica materials, have two nanoscale aspects: nanoscale pores that provide large internal surface areas and nanoscale crystal or particle sizes that may lead to unique external surface reactivity. Zeolites and mesoporous silica have emerged as porous nanomaterials with new properties and many potential applications, in areas such as environmental catalysis, drug delivery, and imaging. The smaller size scale of nanoparticles may increase their toxicity or change the mechanism by which these nanoparticles induce toxicity. Zeolites are crystalline aluminosilicate or silicate materials with very large surface areas due to their pores of less than ∼2 nm. Mesoporous silica is a related porous material that is amorphous and has its pores of greater than ∼2 nm. Zeolites and mesoporous silica are important commercial materials widely used in traditional applications such as catalysis, separations, and water softening. Recently, biomedical applications of zeolites and mesoporous silica in drug delivery, bloodclotting, and imaging are developed. In contrast, amorphous silica nanomaterials are generally thought to be safe and nontoxic. In addition, natural crystalline silica materials, such as quartz and cristobalite, are major constituents of coal mine dust or coal fly ashes. It is therefore of critical importance to study their toxicity.
https://www.researchgate.net/publication/229095421_Chapter_7_-_Toxicity_of_Silica_Nanomaterials_Zeolites_Mesoporous_Silica_and_Amorphous_Silica_Nanoparticles
Hoping this will be helpful,
Rafik
Chapter Chapter 7 - Toxicity of Silica Nanomaterials: Zeolites, Meso...
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