We are working on the synthesis of intermediates required for drug synthesis. Molecules may contain several chiral centres , which will be easy method for resolution of the racemic mixture ?
It depends a lot on the nature of the compound. If you have amine functionalities cristallisation with chiral acids (usually tartaric) is a good option. Likewise if you have carboxylix acid moieties a crystallisation with a chiral base should work.
As far as I know, required by FDA, if a drug candidate has a chiral center you must provide both enantiomeric pairs and their biological response. Therefore if you are preparing a chiral molecule you need to have resolution and determine the absolute stereochemistry. That goes for diasteromeric pairs as well. Sometimes diastereomers are easliy separable by recryst. or purification, but enatiomers you would need prep. chiral column. Good luck..MG
It depends on the enantiomeric ratios, which are purified by the chiral HPLC. The purified compound has to be analyzed by SOR and CD techniques to check the ratios.
The answer to your question is, unfortunately, very case dependent. Without knowing the details it is really virtually impossible to provide good feedback.
In general, resolution of salts with chiral acids or bases, or resolution of esters with chiral acids or alcohols, or resolution of amides with chiral amines or acids are just some examples. Chiral chromatography is another.
For the chiral resolution there are various techniques/methods given in many reviews and textbooks and it is case sensitive, generalization could not be made....I think.
It is possible to provide single chiral molecules as drug entities for use only when the effective separation of the enantiomers is achieved or one isomer is produced in excess over the other enantio-selectively(e,e).
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