I am working on an organ on chip model. For my work I need thermoresponsive and also reversible hydrogel. I am thinking to use GelMA for endothelial cell Addison though its thermoresponsive and gets gelatin at 37 degree. But I am not sure that it is reversible or not that means by changing the temperature, may I convert the solid gelatin state into liquid for easy removal? If anyone has any suggestions please give your valuable responses and also about any other hydrogel which is thermoresponsive and reversible.
We did something similar here: https://www.sciencedirect.com/science/article/pii/S1742706115302579
Our material was not reversible due to covalent crosslinking at 37c. However, if you look at the components that we used, maybe you can use nipaam, HEMA, and Gel-MA as part of your polymer. You will need to adjust the monomers to your exact specifications (gelation, stiffness, porosity, etc.)
I believe this article will help you get to the answer you are looking for.
Article Bioprinting of Thermoresponsive Hydrogels for Next Generatio...
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