Ansys Fluent,  CFX and Multiphysics COMSOL are good tools to simulate the Nanofluid problems. But I think Fluent is the best and use single phase model and change the properties of the fluid according to the specific Nanofluid you used and assume a homogenous fluid.

Dear Arturo, 

Simulation of nanoparticles and liquid mixture (nanofluid) inside Fluent ANSYS is not a big deal. Depend on which model wanted to be taken ( Homogenous or Two-phase) , you can model the nanofluids and survey their mechanical behaviors .

Thank you. I'm interested in the behavior around a single nanoparticle and its comparison with a macroscopic particle

Please help, any ideas or paper published???

I would get an effect like this, 

http://www.google.com.mx/imgres?imgurl=http://www.grc.nasa.gov/WWW/RTE/images/wind/vortex_shedding.jpg&imgrefurl=http://www.grc.nasa.gov/WWW/rte/wind.htm&h=306&w=721&tbnid=ryIsTwHdfHH_wM:&zoom=1&docid=uqwJdiULV3XApM&ei=SA43VYODAe_jsATD3IDgAw&tbm=isch&ved=0CCEQMygGMAY

where the cylinder is a nanopaticula ...

is this possible?

Ansys Fluent,  CFX and Multiphysics COMSOL are good tools to simulate the Nanofluid problems. But I think Fluent is the best and use single phase model and change the properties of the fluid according to the specific Nanofluid you used and assume a homogenous fluid.