Is it possible to induce neurodegeneration with quinolinic acid via i.p and at what dose?
I don't think that is possible. All papers I have read have injected it directly into the brain (and so have I; Lindgren et al., 2013).
Please can you send me this article and explanation on how to inject it into the brain.
Thanks
Here it is. Good luck.
Quinolinic acid is metabolized by quinolinate phosphoribosyltransferase (NAD biosynthesis) present in different cell types.
https://www.researchgate.net/publication/279752635_Expression_of_the_Kynurenine_Pathway_in_Human_Peripheral_Blood_Mononuclear_Cells_Implications_for_Inflammatory_and_Neurodegenerative_Disease
Article Expression of the Kynurenine Pathway in Human Peripheral Blo...
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