Is it possible to induce neurodegeneration with quinolinic acid via i.p and at what dose?

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Hanna Lindgren

I don't think that is possible. All papers I have read have injected it directly into the brain (and so have I; Lindgren et al., 2013).

Ayodele Jacob Akinyemi

Please can you send me this article and explanation on how to inject it into the brain.

Thanks

Here it is. Good luck.

Ricardo Lagoa

Quinolinic acid is metabolized by quinolinate phosphoribosyltransferase (NAD biosynthesis) present in different cell types.

https://www.researchgate.net/publication/279752635_Expression_of_the_Kynurenine_Pathway_in_Human_Peripheral_Blood_Mononuclear_Cells_Implications_for_Inflammatory_and_Neurodegenerative_Disease

Article Expression of the Kynurenine Pathway in Human Peripheral Blo...