This may design hydrogels with alterations in multiple physical properties such as, elasticity, viscosity, pore size and stretchability.
For example, designing hydrogels that can respond to the oxidative stress microenvironment based on how the hydrogels are crosslinked. Design hydrogels with physical properties that can change in response to changes in the biological environment. Further, through the changes in biomechanics caused by the changes in the physical properties of hydrogels, to achieve different roles in different stages of wound repair, such as: early to promote the repair of wounds, in the late healing stage to reduce the formation of scars?
W.T Zhao -- W.T., -- The question you ask is undergoing many new ideas. I included 4 links that should provide an overview of the work as it relates to your question :
1)__ Fracture Toughness and Fatigue Threshold of Tough Hydrogels
https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00788#:~:text=The%20average%20toughness%20is%203375,Na%2Dalginate%2Fpolyacrylamide%20hydrogel
2)__ Thin-film hydrogels with superior stiffness, strength, and stretchability
https://www.sciencedirect.com/science/article/abs/pii/S2352431620300754
3)__ Progress in the mechanical enhancement of hydrogels: Fabrication strategies and underlying mechanisms
https://onlinelibrary.wiley.com/doi/full/10.1002/pol.20220154
4)__ Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres
https://pmc.ncbi.nlm.nih.gov/articles/PMC10160100/
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