The metabolism of most tumor cells is essentially higher than it usually is in most somatic cells. It is reasonable to assume that the tumor cell is much more sensitive to incomes of oxygen and carbohydrates. So, under blocking of feeding arteries, tumor cells should die first. The time needed for this could be set experimentally. So, if the local circulation is recovered after this blockade, we can expect that most of the normal cells will recover too.
Certainly, in the case of not local tumors, special procedures have to provide brain circulation.
To get to the tumour vascular supply is very difficult. It would be affectted the whole organ that contain the tumour. For that reason we preffer to perform surgical resection of tumour. Also, radiotherapy combined with chemotherapy are very effective to reduce the dimensions of solid tumours. It difficult to asses the results of cutting vascular supply, you need to perform CT -PET to follow the results. In the mean time if the tumor is not distroyed, secondary tumour can appear in blood filters of the body( liver, lung, bone, brain).
Dear Florin,
Thanks for your response.
I am not expert in oncology, but my professional interests in general physiology and energetic mechanisms of life compel me to try to explain one fact: the patient on terminal phase of the tumor was spontaneously cured after the circulation of the organism was practically stopped for a several time interval and he was in a coma.
So, the idea I had formulated seemed me to be an approachable explanation. In addition, if it can be a truth, it may lead to an alternative cure method.
This is an interesting question and I don't know if anyone has researched this type of approach or how feasible it would actually be. I think there are multiple aspects of this approach that would need to be considered. The idea of reducing a solid tumour's blood supply has been around for quite some time. For example, Bevacizumab was the first angiogenesis inhibitor used to treat solid tumours, but as I mentioned I am not aware of an approach that would physically block blood supply. (Note: I would be interested to read about something like that so if anyone has papers, so please share any in your reply). There is also a lot of literature on the hypoxic micro-environments within solid tumours and the genotypes and phenotypes of the tumour cells that reside there. Some important considerations would be incorporating research that points to a cancer stem cell niche presence in the hypoxic areas of solid tumours, which are not only less accessible to pharmacological agents because of an already reduced vasculature, but for that reason are also more resistant to low oxygen levels, and perhaps more resistant than normally oxygenated 'normal' tissue.
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