Can a well established cholinergic neurotoxin (AF64A) in animal models be used to induce AD pathology in cell based model of Alzheimer's disease ?
Dear Deeksha,
Do you mean to have to established in vitro culture model systems for neurodegenerative disease. If so please refer following link:
Article Adapting tissue-engineered in vitro CNS models for high-thro...
Hope get some information.
Manju
Article Free-floating adult human brain-derived slice cultures as a ...
Maybe the article can help you with your question.
I hope it helps you.
Rui Milton
Some has used cholinergic neuronal cell lines with AF64A and I guess it depends on what kind of toxin effects with AF64A you would like to see using different brain cell types (e.g., Astrocyte and glial cells? Neurons? Progenitors?).
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