If possible, then there will be no requirement of creating billions of doses for vaccine and cold storage infrastructure. Also it can spread at a high rate and there will be no need of manual vaccination to all. I think in Pandemic times our research of vaccine should be in this way. In conventional method lot of time and money required and for poor and developing countries it will be very difficult to fill demand of vaccine to their people. If some one can create artificially a virus like corona then i think its time to create another virus which can act as vaccine and have low pathogenicity high infectivity and high immunogenicity.
Your idea could be better Dr Rishipal. But there are much chances that the vaccine strain of virus when will come in contact with other naturally existing virus strains, their genome could be mixed and a new more infections, pathogenic strain could evolve due to antigenic shift in various mixing vessels and could pose the world to more deadly new pandemic.
@ Dr. Amarjeet Bisla, Antigenic drift is the reason of most pandemics and this phenomenon is most pronounced in influenza virus, but not all viruses have the same potency. It may be possible that created virus may lead to pandemic, but i don't think. Mutation rate in SARS Cov 2 is slow and it is not showing tendency towards antigenic drift also.
The idea is very interesting, developing countries can have vaccine in free, but researchers will try to avoid because of multiple mutations that may induce pathogenicity in the less pathogenic man made virus
@ Mudassir Khan, You are right. But we can control rate of mutation in an artificial virus (Vaccine). As rates of spontaneous mutation vary amply among viruses. RNA viruses mutate faster than DNA viruses, single-stranded viruses mutate faster than double-strand virus, and genome size appears to correlate negatively with mutation rate. Viral mutation rates are modulated at different levels, including polymerase fidelity, sequence context, template secondary structure, cellular microenvironment, replication mechanisms, proofreading, and access to post-replicative repair.
Please follow the below link
https://www.nature.com/articles/s41565-020-0732-3
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