I am facing some problems regarding steps of OLS, In OLS regression model I have one dependent variable and six explanatory variables. these variables data on the basis of time series.  

 firstly I  have run model without any changes in the variables data (original data) but residual diagnostic shows that serial correlation. After that I  have change my dependent variables in lag 1. then again run OLS but here create another problem such as no statistical significant explanatory variables has been found in my OLS model (only 2 variables are statistical significant out of 6). Here I would like to know how to make significant and is it necessary to take a log entire model (means log for both DV and IV).  

Suggest me how I run OLS appropriate and is it necessary converted into log and take T explanatory variables for the time trend. 

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