In a patient with hereditary desminopathy (mutation Thr341Pro DES in the heterozygous state) over the past three years, an increase in the blood uric acid level up to 440-480 µmol / l was established by 1.5 times (the norm is 428.4 µmol / l). With the progression of the disease, the level has risen and is above normal. It is known that uric acid is an antioxidant. Is it necessary to reduce the level of uric acid? The patient has no problems with the joints.
Dear Viacheslav,
this is a very interesting question. In patients with additional risk factors uric acid reduction can be an option. Defenitely, you want to monitor the level closely. This is because uric acid is not always an antioxidant. This phenomenon is known as the prooxidant urate redox shuttle
theory. Moreover, urate production (not the level) can be problematic when conversion of XDH to xanthine oxidase occurrs. Maybe have a look at this short article
https://www.researchgate.net/publication/308749631_Uric_acid_and_essential_hypertension_The_endothelial_connection
Regards
Boris
Dear Viacheslav Pauls, attached find please some publications concerning our opinion about the potential role of UA and its relationship to vitamin C. My recommendation is following: examine the level of the reduced form of the ascorbic acid and if it is low, replace it as infusion if necessary.
With best regards,
I. Popov
Dear Boris Schmitz and Igor Popov, thank you very much for your answers. The level of ascorbic acid in the blood of a patient with desminopathy within two years is in the range of 4.7 - 6.2 μg / ml (the norm is 4-20 μg / ml).
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