Recently, I have faced with a meta-analysis of clinical trials which included studies performed on adults and 4-8 years old children and combined the effect sizes of both population groups in the overall analysis. I am wondering is it methodologically true? I will be very grateful if anyone can help me with it.
Hamidreza Raeisi-Dehkordi
Can you please share the link to that article?
Article The influence of vitamin D supplementation on IGF-1 levels i...
Yes, you can present the overall effect size in one figure to demonstrate the overall effect of intervention on the general population; however, you have to perform a subgroup analysis according to the age of included population to solve the heterogeneity and compare between the two groups (children and adults).
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