In a cross-sectional study of adults over 50 years of age, the primary outcome is to analyse which participants have subjective cognitive impairment. Is it appropriate to include depression as one of the exclusion criteria for participants?
Yes. Depression can also cause cognitive impairment. Attention deficit is one of the significant criteria for diagnosing depression. This can further lead to cognitive decline. Hence, depression can be an 'exclusion' criterion in a study designed to explore cognitive impairment.
Yes. But, how do you know of depression. It could be a clear and present diagnosis. It could also be mild or temporary, and thus unaware. The consequence can be cognitive impairment. However cognitive impairment can lead to depression. A clear definition of depression is necessary as well as the dignostic criteria of the severeness for this study.
Yes, that could be reasonable for exclusion criteria. Considering the environmental factors impacting depression, many may have experienced an abusive or neglectful upbringing. With a neglectful background, it's reasonable to expect that they have not received adequate cognitive stimulation in their development, leading to impairment in cognitive abilities.
All the best with your study!
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