Is IRE1 upregulated in reponse to ATF4 activation?

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Ali Hassan Daghir Janabi

Some researches say "yes"

Caroline Hild Hakvåg Pettersen

IRE1 is one of 3 ER stress sensor proteins (together with ATF6 and PERK). Upon ER stress one or more of these proteins may become activated. IRE1 does not lay downstream from ATF4, which is activated after PERK phohsphorylates eIF2a, but they may affect common down stream targets like XBP-1 and CHOP.

Please see http://www.jbc.org/content/early/2004/01/23/jbc.M313724200.full.pdf

and https://www.nature.com/articles/srep24217