1. Is silver nanoparticle in doses of 100 and 200 micromole intraperitoneal suffient to induce toxicity without killing the rats?
2. Can curcumin be used as hepatoprotective for liver injury induced by silver nanoparticles. Does curcumin degrade in presence of silver nanoparticles?
1. You should discuss these questions with the author :)
2. Some data: 100 micro mole silver are 10.8 mg nano-silver particles. According to (Silver Nanotechnology Working Group. Re: Silver Nanoparticles (AgNPs); Information and Common Request. CDC-2012-0014; NIOSH-260. Comments of the Silver Nanotechnology Working Group for review by the National Institute for Occupational Safety and Health (NIOSH). February 2013), ORAL NOAEL in rats is 30 mg nano-silver/kg/day. Considering 250 g per adult rat, this is 7.5 mg nano-silver /kg/day, which caused no observational effects after oral intake. However, I do not know the relevance for intraperitoneal application.
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