The immune systems of COVID-19 survivors figured out how to combat and defeat the invading SARS-CoV-2 virus. Neutralizing antibodies are one kind of immunological front-line response. These antibodies are proteins that are secreted by immune cells called B lymphocytes when they encounter an invader, such as a virus. Antibodies recognize and bind proteins on the surface of virus particles. For each infection, the immune system designs antibodies that are highly specific for the particular invading pathogen. Passive immunization is a process in which neutralizing antibodies from one individual can be used to protect or treat another.
Convalescent plasma therapy can serve as a promising rescue option for severe COVID-19.
https://www.pnas.org/content/pnas/early/2020/04/02/2004168117.full.pdf
Petru Emil Muntean Not yet know. New York city in the US is testing it right now.
Sheba Medical Center in Israel has been testing it. Your should contact them.
Yes! Please see the links below.
https://jamanetwork.com/journals/jama/fullarticle/2763983
https://www.thelancet.com/action/showPdf?pii=S1473-3099%2820%2930141-9
https://www.bmj.com/content/bmj/368/bmj.m1256.full.pdf
https://www.medrxiv.org/content/10.1101/2020.03.16.20036145v1.full.pdf
The following figure is a proposed scheme of treatment in the different phases of COVID-19 infection. It is based on ongoing research and some personal insights.
You may take the following as reference:
Effectiveness of convalescent plasma therapy in severe COVID-19 patients
Kai Duan, et al
Proceedings of the National Academy of Sciences Apr 2020, 202004168;
DOI: 10.1073/pnas.2004168117
Dear Juan Baez
Nothing has been adopted as a seminal treatment, however enough is known now to plan a rational therapy along the lines I described above. To this you should add anticoagulants and eventually xsanguineotransfusion.
Dear Nasir Mustafa
It is not with newspaper excerpts that work the scientific world.
Convalescent plasma therapy can serve as a promising rescue option for severe COVID-19.
https://www.pnas.org/content/pnas/early/2020/04/02/2004168117.full.pdf
COVID-19 is currently a big threat to global health. However, no specific antiviral agents are available for its treatment. In this work, we explore the feasibility of convalescent plasma (CP) transfusion to rescue severe patients. The results from 10 severe adult cases showed that one dose (200 mL) of CP was well tolerated and could significantly increase or maintain the neutralizing antibodies at a high level, leading to disappearance of viremia in 7 d. Meanwhile, clinical symptoms and paraclinical criteria rapidly improved within 3 d. Radiological examination showed varying degrees of absorption of lung lesions within 7 d. These results indicate that CP can serve as a promising rescue option for severe COVID-19, while the randomized trial is warranted.
Read more information in detail through interesting research articles through the below links.
https://www.pnas.org/content/early/2020/04/02/2004168117
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 not yet has established its treatment, but convalescent plasma has been expected to increase survival rates as in the case with other emerging viral infections.
Read more information in detail through interesting research articles through the below links.
Article Use of Convalescent Plasma Therapy in Two COVID-19 Patients ...
Convalescent plasma is an antibody-rich product made from blood donated by people who have recovered from the disease caused by the virus. Prior experience with respiratory viruses and limited data that have emerged from China suggest that convalescent plasma has the potential to lessen the severity or shorten the length of illness caused by COVID-19. It is important that we evaluate this potential therapy in the context of clinical trials, through expanded access, as well as facilitate emergency access for individual patients, as appropriate.
Read more information in detail through interesting research articles through the below links.
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-encourages-recovered-patients-donate-plasma-development-blood
Probably yes. The affirmative answer to this question is based on knowledge of virology built over many years in the past. However, the lack of full certainty in the answer is due to the fact that we are dealing with a new type of virus that has relatively recently attacked a person and research was carried out for too short a time. Until the vaccine is created, it can be a good therapy to support the treatment of people who have Covid-19. However, in order to fully answer the above question, it is necessary to conduct research in this field for the next minimum several weeks or months. People whose natural immune system has fought SARS-CoV-2 Coronavirus have antibodies to this virus in their blood plasma. However, we do not know how long this natural immunity will persist. We do not know whether in subsequent years, as a result of constant mutations of the SARS-CoV-2 Coronavirus, new varieties of this virus with significantly different characteristics of infectivity and pathogenicity will not develop, and whether the current natural immunity resulting from antibodies produced in the body of a person recovering from Covid-19 disease and whether these new varieties of this virus will become resistant to antibodies generated during the control of the previous version of the current version of the SARS-CoV-2 Coronavirus. In addition, the health of individuals, which is determined by many factors, including other diseases, a specific lifestyle and diet can also have a significant impact on the natural immune system of the human body. This effect may be even greater for the production of said antibodies than administration of these antibodies to another person having Covid-19. So there are many questions that require continuing research in this field.
Regards,
Dariusz Prokopowicz
People who've recovered from COVID-19 have antibodies to the disease in their blood. Doctors call this convalescent plasma. Researchers hope that convalescent plasma can be given to people with severe COVID-19 to boost their ability to fight the virus.
Please read this article.
Please have a look at the following link:
Article Convalescent Plasma Therapy for Corona Virus Disease 2019: a...
Yes, it is effective considering its content of anti-COV high affinity neutralizing IgG antibodies. Also specially for immunocompromised patients and those with severe disease.
It requires highly specialized settings and it needs to be screened for hepatitis and HIV viruses before administration.
Another thing is that it's not used for mild cases and only tried for severe cases in my country.
Dear Petru E. M., in Indonesia has begun to be carried out but its effectiveness has not been empirically informed to the public. regards and stay healthy.
Please also go through the following RG links.
Article Convalescent Plasma a Potential Therapy in Covid-19 Patients...
Article Convalescent plasma: A possible treatment of COVID-19 in India
@ Petru Emil Muntean
https://www.thehindu.com/news/national/tamil-nadu/convalescent-plasma-therapy-successful-in-18-patients
It might be effective, but still needs more research on convalescent plasma.
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