Hi Dear professor,
In addition to interest project, i and my college want start to new project as title the effect of HPV infection in clinical and pathological different stages.
Hi,
According to the literature, cannabinoid system plays a significant role in pathophysiologic process such as immune function. However, the outcome on the viral infection will depend on whether immune function is involved in the specific cases. In the field of cannabinoids and viral infection there is no study regarding the HPV infection. Please read our comprehensive review for more information about cannabinoids and viral infection.
Effects of Cannabinoids and their Receptors on Viral Infections.Journal of Medical Virology.
Hi dear;
OLUME 4 SUPPLEMENT 2
Proceedings of the 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research
POSTER PRESENTATION
OPEN ACCESS
Marijuana use and cervical HPV/neoplasia
G D'Souza,
R Burk,
Y Zhong,
H Minkoff,
LS Massad,
K Anastos,
A Levine,
M Moxley,
X Xue,
J Palefsky and
HD Strickler
Infectious Agents and Cancer20094(Suppl 2):P15
DOI: 10.1186/1750-9378-4-S2-P15
© D'Souza et al; licensee BioMed Central Ltd. 2009
Published: 17 June 2009
Recent research suggests that marijuana use may be positively associated with risk of human papillomavirus (HPV)-associated oropharyngeal cancer, and the immunomodulatory effects of cannabinoids are considered a possible mechanism. Were marijuana to have systemic effects on HPV-associated tumorigenesis it would be of major concern, and might be especially harmful in immunologically susceptible populations such as HIV-positive women.
We studied the effect of marijuana use on cervical HPV natural history and cervical squamous intraepithelial lesions (SIL) among HIV-positive and HIV-negative women in the Women's Interagency HIV Study (WIHS), a large prospective cohort study. HPV DNA testing by PCR and Pap smears were conducted semi-annually. Prevalent HPV and cervical SIL were analyzed using logistic regression with GEE. Persistence of HPV was analyzed using Cox regression.
Of the 3,499 women in the WIHS, 1,414 reported ever using marijuana. There were no associations between HPV prevalence and either current (OR = 0.98 95% CI = 0.90–1.07), frequent (current daily use: OR = 0.98 95 CI = 0.90–1.07), or sustained (daily use for more than 3 years: OR = 1.03, 95% CI = 0.90–1.19) marijuana use, controlling for age, race, HIV status, CD4 cell count, number of sexual partners in the last 6 months, tobacco use and cervical treatment. Nor were there effects on prevalence of SIL, or on the persistence of cervical HPV infection. Results were similar among HIV-negative and HIV-positive women.
Our data do not support an effect of marijuana on cervical HPV infection, persistence or risk of cervical dysplasia. If there is an effect of marijuana use on oral HPV-associated tumorigenesis, it may be a local effect.
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