In a general perspective, Katp channels link metabolic state of the cell to its electrical activity thereby exhibiting variety of functions such as cardioprotection, insulin secretion etc., Invitro experiments performed by Crawford et al., 2003, reported that the gene expression of cardiac specific regulatory subunit (SUR2A) of Katp channels was a HIF independent process. Moreover, recent invivo studies conducted by Mohammed Abdul KS et al., 2014, revealed the expression of cardioprotective regulatory subunit (SUR2A) via subtle change in oxygen tension that possibly can't activate HIF signalling pathway lead to increase in SUR2A protein in mice heart (via., ERK signalling pathway).
So I was interested to know whether does this rule applies on all Katp channels that are expressed and assembled in a tissue specific manner ie., brain, pancreas, etc. Or else does it changes with tissue types?
it apperas to be. read the following aper for more info:
See comment in PubMed Commons belowPLoS One. 2013 Jul 25;8(7):e67498. doi: 10.1371/journal.pone.0067498. Print 2013.
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells.
Ma Z1, Moruzzi N, Catrina SB, Hals I, Oberholzer J, Grill V, Björklund A.
good luck.
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