Is anyone familiar with poly vinyl acetate as a PLA nanoparticle stabilizer?

18 November 2014 1 7K Report

I am trying to ultimately produce PLA nanoparticles dispersed in water, less than 600 nm in size. My process so far involves antisolvent precipitation with dichloromethane + methanol of L-PLA + PLA-PEG block copolymer as stabilizer. The particles formed are very nice, but after drying they do not redisperse well. Since PVA is not soluble in methanol, I was considering using PVAc instead to allow for better redispersion in water. Is this feasible?

Qiang Zhang

It is very easy!

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