I am writing a paper on "colon cancer and nutrients". While searching for literature a point hit my mind: can bacterial infection be one cause of colon cancer?.
There has been some work published in this area, particularly in the sulfate reducing bacteria and the local effects on the mucosa. No doubt post-translational modifications associated with the relationship with the luminal gut flora and the nutrients etc will be linked - hence the data on salicylates etc.
Different oncoviruses and bacteria have been incriminated for causing various malignancies.Regarding colorectal cancer, there is evidence of association of streptococcus bovis but the role in carcinogenesis, if any, is still unclear.Regarding gastric cancer,CagA has been incriminated by H pylori infection.We may come to know the definite role in future.
This is a very interesting question. For sure, gutome (that is to say, human gut microbiome, see http://gutome.com/, OMICS A Journal of Integrative Biology Volume 15, 2010, DOI: 10.1089/omi.2010.0109) plays an important role in neoplastic transformation. A systems approach is absolutely mandatory and omics sciences could provide molecular details of the various processes.
The answer to your question is "Yes". Please go through the following RG links.
Article Association of Helicobacter pylori Infection With Colon Canc...
Article Helicobacter pylori Infection and Colorectal Cancer Risk: Ev...
Article Helicobacter pylori infection and colorectal carcinoma: Path...
Article Helicobacter pylori in Colorectal Carcinoma Tissue
Article Bacterial Infection as a Cause of Cancer
Please also have a look at the following RG links.
Article Helicobacter pylori and colorectal cancer—A bacterium going abroad?
Article Association of Helicobacter Pylori Infection and Colon Cancer
Article Helicobacter pylori infection increases the risk of colorect...
Article Helicobacter pylori infection and the risk of colorectal can...
Streptococcus bovis bacteremia is classically associated with colorectal cancer. A number of other bacterial species have been found in colorectal cancer microbiota and may even exert oncogenic effects.
Please also go through the following RG links.
Article Role of gut microbiota in the pathogenesis of colorectal can...
Article The Role of the Gut Microbiota in Colorectal Cancer Causation
Article Microbial dysbiosis and colon carcinogenesis: Could colon ca...
Article Microbiome and colorectal cancer: Roles in carcinogenesis an...
Article Gut microbiota, inflammation and colorectal cancer
Article Significance of Infectious Agents in Colorectal Cancer Development
Yes, dear Arvind Singh , Gave the publication in detail. Helicobacter is known to mediate the development of this process. Regards, Sergey Viktorovich Pushkin
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