I'm dealing with a small sample size and my categorical variables tend to be 4 vs 2 or 8 vs 0 in terms of their numerical value. Does this make a Chi Square less powerful or even an inappropriate test to run?

Thank you in advance!

P.S. My suspicion is it does not -- my sample size is 76 and I may just need to address it

Edit: I've attached an image of what I am dealing with -- I don't think Fisher's will work.

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