I have some mice in which we have induced focal gastrointestinal ulcers with bleeding at least in the first two weeks post injury, and we observed anemia from two weeks to two months post injury. At two months I see complete ablation of bone marrow iron stores using Prussian blue staining but moderately increased tissue iron stores in the spleen and liver. This is accompanied by a reticulocytosis and increased extramedullary hematopoiesis. Does anyone have any explanation for this decrease and increase? And does this fit better with iron deficiency or anemia of chronic disease? I also have increased serum il6 at two weeks post injury which is leading me down the ACD track despite the fairly classic IDA presentation.
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