Iron amino acid chelate like Ferrous bis-glycine chelate should be taken on empty stomach or it should be taken with a meal to prevent GI upset?
Since the absorption of ferrous containing formulations needs adequate level of HCL and acidity to be present in the stomach, i would suspect that eating certain foods may neutralize acidity and thus decrease bioavailability of your iron amino acid chelate. However, stomach upset is possible in which case compensation can be made and the supplement should be taken with food.
The bioavailability of iron bis glycine chelate is mainly affected by iron stores in our body. The effect of meal on absorption of iron bis glycine chelate often depends upon on the type of the food. For example, milk inhibits absorption of iron bis glycine chelate where as foods with high ascrobic acid content increases absorption of iron bis glycine chelates
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