I've been looking at the ranges in which a drug is considered to have low or high intrinsic clearance and I have having a hard time finding what is the acceptable numbers of which a drug is considered to low high intrinsic clearance. When I did find something, it was simply explained as the "bands typically used for categorizing compounds into... " (link below); but what is that based on?
https://www.cyprotex.com/admepk/in-vitro-metabolism/microsomal-stability
Liver metabolism is the major route for elimination for a wide variety of drugs & it can be affected by a variety of parameters. Hepatic drug clearance can be defined as the volume of blood perfusing the liver that is cleared of the drug per unit of time.
There are three major parameters that determine drug elimination by the liver:
The ratio of the hepatic clearance of a drug to the hepatic blood flow is called the extraction ratio of the drug. Extraction ratio can be generally classified as high (>0.7), intermediate (0.3-0.7) or low (
the drugs are classified into 3 categories on the basis of ER values:
High with ER >0.7
intermediate ER= 0.3-0.7
low ER=
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