I am advising a researcher on using abaqus to run a mechanobiology simulation which requires the calculation of the interstitial fluid flow. The calculation is based on an equation from Prendergasts work in mechanoregulation such that the stimuli on stem cells may be used to calculate their differentiation.
The stimuli S is determined by empirical constants, the octahedral shear strain, and the interstitial fluid flow v in the extracellular environment of cells (see attached paper). We are unable to find a setting in abaqus to output the interstitial fluid flow as a field output variable.
We are using Abaqus/CAE 6.14, performing the FEA on a porous elastic material, and using pressure elements (C3D4P) for the meshing phase.
In summary, we are asking for help in finding the interstitial fluid flow values as an output for a porous elastic material subject to a loading condition in abaqus, when a model consists of a scaffold structure and a poroelastic material representative of a granulation tissue where cells may differentiate according to the aforementioned stimuli.
Dear paul
i have seen you asked this question 3 years ago.
i am searching an actually did some project in respect of bone mechanobiology.
Are you looking for your question's answer yet?
Hi Gholamreza, I thought somebody had answered this before, but there are setting ins abaqus that make it fairly simple, if you know the correct options to choose. We ultimately chose to go with a simpler simulation written in python, that way we weren't reliant on abaqus software in the future. If I come across a more detailed answer I will post. But generally you need a poroelastic modulus and then to have values for the materials set for modulus of elasticity, poisson ratio, grain bulk modulus, fluid bulk modulus, permeability, specific weight, and void ratio.
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