T-test and Mann-Whitney U test on groups with different sample sizes and variances?

Hello I have 2 groups with different sample sizes of (experts: 5 to 8) and (Users: 28 to 35) answering 21 questions on a 7 points Likert scale about the importance of some dimensions for...

31 January 2021 3,885 7 View

What are the types of optimization problems that can't be tackled by meta-heuristic and heuristic algorithms?

Any decision-making problem when precisely formulated within the framework of mathematics is posed as an optimization problem. There are so many ways, in fact, I think infinitely many ways one can...

06 September 2020 9,415 14 View

Is it possible to reduce tensile strength and increase compressive strength by adding any admixture to concrete?

Hello, I want to know is it possible that the compressive strength of concrete increase by reducing tensile strength? if yes, how we can explanation and justification this issue?

30 April 2020 4,489 7 View

What are the plans for exams and assessments of universities during corona virus pandemy?

What alternative ways universities use for academic assesment of students?

29 April 2020 3,091 1 View

Is there a specific way to discretize a continuous model to any arbitrary multi DOF system and extract the mode shape matrix in abaqus?

27 April 2020 239 3 View

What is best sampling method for cross sectional studies?

I want to research on liver disease patients behaviours and habits in shiraz city. How can I calculate sample size accurately? Thanks

23 March 2020 9,974 5 View

Anyone in kolkata working of LNCaP prostate cells?

I am working with prostate cancer cells, i want to know who is presently working with PCa cell lines in viro and in vivo in kolkata.any leeds will of great help.

07 March 2020 7,831 1 View

How can I find the IDT point of the following TGA curve which is related to a clay soil?

The attached file shows the TGA curve of a clay soil. Can anyone help me how to recognize the initial decomposition temperature (IDT) from this curve?

06 February 2020 6,944 3 View

How to isolate dorsal root ganglia in rat at lumber region?

For pathological investigation of sensory and motor nerves in lumber region of rat how to isolate and preserve

04 November 2019 8,974 1 View

What's the procedure for validation test of a new design of product (Say Heat Exchanger)?

after 3D design of all components of the Heat Exchanger geometry we do assembly and finalization of the geometry, in CFD analysis we change the boundary conditions and it refers us to the...

27 October 2019 9,095 3 View

What is the production process of CaFe ferroalloys?

I looking for ferro calcium production process

03 March 2021 1,755 4 View

What element is driving the different slop in the low frequency tail?

My study consists simple corrosion inhibitors in salty brine. Right now I just fit my circuit with randles with CPE. Just wondering how the slop can given more info of the experiment. Or any...

01 March 2021 6,474 3 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

Did anyone perform CD107a degranulation assay without the use of inhibitors like monensin?

I am planning to perform a degranulation assay using CD107a antibody. Some resources suggest to use inhibitors like monensin to inhibit the intracellular traficking and acidification of the...

21 February 2021 6,260 3 View

Phenol-pH graphic?

We want to use phenol pH graphic to measure the pH of mediums before and after inhibitor application to cells. We have phenol absorbence values at 460, 560 and 720 nm wavelength. When we measure...

20 February 2021 7,700 3 View

Which way will be better to give OGT inhibitors doses through intravenous or orally for pregnant female rats and concentration suggestion?

I'm planning to use ST078925 OGT inhibitor from TimTec (OGT-O-linked N-acetylglucosamine (GlcNAc) transferase) for female rats.

16 February 2021 7,850 2 View

How long does it take to design and validate transition state analogue inhibitors?

Hi, I'm asking from the point of view of designing a research plan: How long (approximately) can it take to determine the transition state structure of an enzyme substrate using kinetic isotope...

14 February 2021 2,610 1 View

Purified protein requires Calcium for activation, but the elution buffer I used seems to interact with Calcium, help?

09 February 2021 6,946 4 View

Why am I getting such large heats of dilution in my Isothermal Titration Calorimetry Experiment?

I am trying to measure binding of calcium to an expressed protein we are studying and am getting very large heats of dilution for the calcium solution in my control tests. We prepared a 1 M CaCl2...

07 February 2021 7,532 1 View

Has anybody administered MK-2206 (an orally active, allosteric inhibitor of AKT) intravenously to the mice?

We aim to use MK-2206 to inhibit AKT in mice. However, a large body of studies suggests that it should be administered orally. I was wondering if somebody could tell me that is it toxic for the...

07 February 2021 6,340 1 View